| Date | Opponent | Result | Home / Away | Time | Location | Television |
| Nov. 2 (Wed.) |
NORTHERN STATE (S.D.) [Exh.] |
W 80 – 51 |
H | 7:00 p.m. | Lexington, KY | FSN-S |
| Nov. 9 (Wed.) |
GEORGETOWN (Ky.) [Exh.] | W 85 – 63 |
H | 7:00 p.m. | Lexington, KY | FSN-S/BBSN |
Guardians Classic |
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| Nov. 13 (Sun.) |
SOUTH DAKOTA STATE |
W 71 – 54 |
(1) | 8:00 p.m. | Lexington, KY | ESPNU |
| Nov. 14 (Mon.) |
NORTHERN COLORADO/LIPSCOMB |
W 67 – 49 |
(1) | 8:00 p.m. | Lexington, KY | ESPNU |
| Nov. 21 (Mon.) | Iowa | L 63 – 67 | (2) | TBA | Kansas City, MO | ESPN2 |
| Nov. 22 (Tue.) | West Virginia | W 80 – 66 | (2) | TBA | Kansas City, MO | ESPN2 |
| Nov. 25 (Fri.) |
LIBERTY |
W 81 – 51 |
H | 7:00 p.m. | Lexington, KY | FSN-S |
| Nov. 29 (Tue.) |
HIGH POINT |
W 75 – 55 |
H | 7:00 p.m. | Lexington, KY | FSN-S |
| Dec. 3 (Sat.) |
NORTH CAROLINA |
L 79 – 83 |
H | Noon | Lexington, KY | CBS |
| Dec. 6 (Tue.) | Georgia State | W 73 – 46 | (3) | 8:00 p.m. | Atlanta, GA | ESPNU |
| Dec. 10 (Sat.) | Indiana | L 53 – 79 | (4) | 3:45 p.m. | Indianapolis, IN | CBS |
| Dec. 17 (Sat.) |
LOUISVILLE |
W 73 – 61 |
H | 2:00 p.m. | Lexington, KY | CBS |
| Dec. 23 (Fri.) | Iona | W 73 – 67 | (5) | 7:00 p.m. | Louisville, KY | FSN |
| Dec. 30 (Fri.) | Ohio | W 71 – 63 | (6) | 8:00 p.m. | Cincinnati, OH | ESPN1 |
| Jan. 3 (Tue.) |
CENTRAL FLORIDA |
W 59 – 57 |
H | 7:00 p.m. | Lexington, KY | FSN |
| Jan. 7 (Sat.) | Kansas | L 46 – 73 | A | Noon | Lawrence, KS | ESPN |
| Jan. 10 (Tue.) |
VANDERBILT |
L 52 – 57 |
H | 9:00 p.m. | Lexington, KY | ESPN |
| Jan. 14 (Sat.) |
ALABAMA |
L 64 – 68 |
H | 1:00 p.m. | Lexington, KY | CBS |
| Jan. 17 (Tue.) | Georgia | W 69 – 55 | A | 9:00 p.m. | Athens, GA | ESPN |
| Jan. 21 (Sat.) |
SOUTH CAROLINA |
W 80 – 78 |
H | 1:00 p.m. | Lexington, KY | JP |
| Jan. 24 (Tue.) | Auburn | W 71 – 62 | A | 7:00 p.m. | Auburn, AL | ESPN |
| Jan. 29 (Sun.) |
ARKANSAS |
W 78 – 76 |
H | 1:00 p.m. | Lexington, KY | CBS |
| Feb. 1 (Wed.) | Mississippi State |
W 81 – 66 | A | 8:00 p.m. | Oxford, MS | JP |
| Feb. 4 (Sat.) | Florida | L 80 – 95 | A | 9:00 p.m. | Gainesville, FL | ESPN2 |
| Feb. 7 (Tue.) |
TENNESSEE |
L 67 – 75 |
H | 7:00 p.m. | Lexington, KY | ESPN |
| Feb. 11 (Sat.) | Vanderbilt | L 81 – 84 | A | 3:00 p.m. | Nashville, TN | JP |
| Feb. 15 (Wed.) |
GEORGIA |
W 68 – 61 |
H | 8:00 p.m. | Lexington, KY | JP |
| Feb. 18 (Sat.) | South Carolina |
W 79 – 66 | A | 1:30 p.m. | Columbia, SC | CBS |
| Feb. 22 (Wed.) |
OLE MISS |
W 80 – 40 |
H | 8:00 p.m. | Lexington, KY | JP |
| Feb. 25 (Sat.) | LSU | L 67 – 71 | A | 3:45 p.m. | Baton Rouge, LA | CBS |
| Mar. 1 (Wed.) | Tennessee | W 80 – 78 | A | 8:00 p.m. | Knoxville, TN | JP |
| Mar. 5 (Sun.) |
FLORIDA |
L 64 – 79 |
H | Noon | Lexington, KY | CBS |
SEC Tournament |
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| Mar. 10 | Mississippi | W 71 – 57 | (7) | TBA | Nashville, TN | |
| Mar. 11 | South Carolina | W 68-61 | (7) | TBA | Nashville, TN | |
|
NCAA Tournament |
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| Mar. 17 | Alabama-Birmingham | W 69-64 | (8) | TBA | Philadelphia, PA | |
| Mar. 19 | Connecticut | L 83-87 | (8) | TBA | Philadelphia, PA | |
White = Home Game
Silver = Away Game
1 = Guardians Classic (Rupp Arena, Lexington, Ky.)
2 = Municipal Auditorium (Kansas City, Mo.)
3 = Philips Arena (Atlanta, Ga.)
4 = RCA Dome (Indianapolis, Ind.)
5 = Freedom Hall (Louisville, Ky.)
6 = US Bank Arena (Cincinnati, Ohio)
7 = Gaylord Entertainment Center (Nashville, Tenn.)
8 = NCAA Tournament, Philadelphia, PA
