| 2021-10-10 17:30:06October 10, 2021 | | 17:30:065:30 pm | | Rupp Arena |
| 2021-10-15 19:00:32October 15, 2021 | | 19:00:327:00 pm | | Rupp Arena |
| 2021-10-29 19:00:14October 29, 2021 | Kentucky | 95 - 72 | Kentucky Wesleyan | Rupp Arena |
| 2021-11-05 19:00:28November 5, 2021 | Kentucky | 80 - 71 | Miles College | Rupp Arena |
| 2021-11-09 21:30:50November 9, 2021 | Kentucky | 71 - 79 | Duke | Madison Square Garden |
| 2021-11-12 19:00:37November 12, 2021 | Kentucky | 100 - 60 | Robert Morris | Rupp Arena |
| 2021-11-16 19:00:35November 16, 2021 | Kentucky | 80 - 50 | Mount St. Mary’s | Rupp Arena |
| 2021-11-19 19:00:20November 19, 2021 | Kentucky | 77 - 59 | Ohio | Rupp Arena |
| 2021-11-22 19:00:35November 22, 2021 | Kentucky | 86 - 61 | Albany | Rupp Arena |
| 2021-11-26 19:00:11November 26, 2021 | Kentucky | 86 - 52 | North Florida | Rupp Arena |
| 2021-11-29 19:00:53November 29, 2021 | Kentucky | 85 - 57 | Central Michigan | Rupp Arena |
| 2021-12-07 19:00:01December 7, 2021 | Kentucky | 76 - 64 | Southern University | Rupp Arena |
| 2021-12-11 17:15:01December 11, 2021 | Notre Dame | 66 - 62 | Kentucky | Joyce Center |
| 2021-12-18 17:15:33December 18, 2021 | Ohio State | 17:15:33Canceled | Kentucky | T-Mobile Arena (Las Vegas) |
| 2021-12-18 17:30:28December 18, 2021 | Kentucky | 98 - 69 | North Carolina | T-Mobile Arena (Las Vegas) |
| 2021-12-22 17:00:43December 22, 2021 | Kentucky | 95 - 60 | WKU | Rupp Arena |
| 2021-12-22 18:00:46December 22, 2021 | Kentucky | 18:00:46Canceled | Louisville | Rupp Arena |
| 2021-12-29 19:00:29December 29, 2021 | Kentucky | 83 - 56 | Missouri | Rupp Arena |
| 2021-12-31 12:00:10December 31, 2021 | Kentucky | 92 - 48 | High Point | Rupp Arena |
| 2022-01-04 19:00:17January 4, 2022 | Louisiana State | 65 - 60 | Kentucky | Pete Maravich Assembly Center |
| 2022-01-08 18:00:14January 8, 2022 | Kentucky | 92 - 77 | Georgia | Rupp Arena |
| 2022-01-11 19:00:37January 11, 2022 | Vanderbilt | 66 - 78 | Kentucky | Memorial Gymnasium |
| 2022-01-15 12:00:14January 15, 2022 | Kentucky | 107 - 79 | Tennessee | Rupp Arena |
| 2022-01-19 20:30:20January 19, 2022 | Texas A & M | 58 - 64 | Kentucky | Reed Arena |
| 2022-01-22 13:00:55January 22, 2022 | Auburn | 80 - 71 | Kentucky | Auburn Arena |
| 2022-01-25 21:00:20January 25, 2022 | Kentucky | 82 - 74 | Mississippi State | Rupp Arena |
| 2022-01-29 18:00:48January 29, 2022 | Kansas | 62 - 80 | Kentucky | Allen Fieldhouse |
| 2022-02-02 19:00:23February 2, 2022 | Kentucky | 77 - 70 | Vanderbilt | Rupp Arena |
| 2022-02-05 20:00:35February 5, 2022 | Alabama | 55 - 66 | Kentucky | Coleman Coliseum |
| 2022-02-08 19:00:43February 8, 2022 | South Carolina | 76 - 86 | Kentucky | Colonial Life Arena |
| 2022-02-12 16:00:28February 12, 2022 | Kentucky | 78 - 57 | Florida | Rupp Arena |
| 2022-02-15 21:00:03February 15, 2022 | Tennessee | 76 - 63 | Kentucky | Thompson-Boling Arena |
| 2022-02-19 13:00:31February 19, 2022 | Kentucky | 90 - 81 | Alabama | Rupp Arena |
| 2022-02-23 21:00:47February 23, 2022 | Kentucky | 71 - 66 | Louisiana State | Rupp Arena |
| 2022-02-26 14:00:25February 26, 2022 | Arkansas | 75 - 73 | Kentucky | Bud Walton Arena |
| 2022-03-01 19:00:04March 1, 2022 | Kentucky | 83 - 72 | Mississippi | Rupp Arena |
| 2022-03-05 14:00:33March 5, 2022 | Florida | 63 - 71 | Kentucky | O'Connell Center |
| 2022-03-11 20:00:46March 11, 2022 | Kentucky | 77 - 71 | Vanderbilt | Amalie Arena |
| 2022-03-12 15:00:44March 12, 2022 | Kentucky | 62 - 69 | Tennessee | Amalie Arena |
| 2022-03-17 19:10:10March 17, 2022 | Kentucky | 79 - 85 | Saint Peter’s University | Gainbridge Fieldhouse |