Trey Lyles scored 14 points, Andrew Harrison added 13 and the unbeaten Wildcats, chasing history and a ninth national title, rolled into the Elite Eight.
Kentucky (37-0) advanced to Saturday's regional final to play third-seeded Notre Dame.
With stunning ease, the Wildcats built a 26-point lead in the first half over the Mountaineers (25-10), who led the nation in steals and figured their full-court press would at least bother Kentucky into some turnovers. West Virginia shot only 24.1 percent (13 of 54), including 2 of 15 from 3-point range.
West Virginia didn't eclipse 20 points until the 11:41 mark of the second half.
Juwan Staten scored 14 points to lead West Virginia.
Walter Cornett, of Glendale, Kentucky, is the owner and operator of Walter's Wildcat World. He founded WildcatWorld.com in 1998 making it one of the oldest Kentucky basketball fan sites in operation today.