Trey Lyles scored 14 points, Andrew Harrison added 13 and the unbeaten Wildcats, chasing history and a ninth national title, rolled into the Elite Eight.
Kentucky (37-0) advanced to Saturday’s regional final to play third-seeded Notre Dame.
With stunning ease, the Wildcats built a 26-point lead in the first half over the Mountaineers (25-10), who led the nation in steals and figured their full-court press would at least bother Kentucky into some turnovers. West Virginia shot only 24.1 percent (13 of 54), including 2 of 15 from 3-point range.
West Virginia didn’t eclipse 20 points until the 11:41 mark of the second half.
Juwan Staten scored 14 points to lead West Virginia.