Kentucky (1-5) has lost five in a row for the first time since John Calipari became coach in 2009.
Kerwin Walton scored 13 points and fellow freshman guard Caleb Love had 11 points and six assists for the Tar Heels (5-2), who outscored the Wildcats 33-15 to end the game.
Kentucky’s Davion Mintz scored 17 points — making all three of the Wildcats’ 3-pointers — and grabbed eight rebounds.
Walton scored eight points in a 9-1 game-changing run by the Tar Heels, including the go-ahead free throw at 50-49 with 11:42 remaining. North Carolina had trailed by 11 in the first half.