Trey Lyles scored a career-high 18 points and Aaron Harrison added 16 for Kentucky (28-0, 15-0 Southeastern Conference), which is the last remaining undefeated team in the country.
Its 28 straight wins are the most in a single season in program history.
The Wildcats had to work a little for this one, leading just 41-37 with 15:10 remaining. But they responded with an avalanche of points down the stretch – punctuated by a thunderous dunk by Karl-Anthony Towns – to turn the contest into another convincing blowout.
Mississippi State (12-16, 5-10) has lost eight in a row to the Wildcats. Fred Thomas led the Bulldogs with 14 points.
Walter Cornett, of Glendale, Kentucky, is the owner and operator of Walter's Wildcat World. He founded WildcatWorld.com in 1998 making it one of the oldest Kentucky basketball fan sites in operation today.