| 2020-11-12 19:00:19November 12, 2020 | Pro Day | 19:00:197:00 pm | Memorial Coliseum |
| 2020-11-20 21:00:21November 20, 2020 | Big Blue Madness | 21:00:219:00 pm | Memorial Coliseum |
| 2020-11-25 18:00:15November 25, 2020 | Morehead State University | 45 - 81 | Rupp Arena |
| 2020-11-29 13:00:05November 29, 2020 | University of Richmond | 76 - 64 | Rupp Arena |
| 2020-12-01 21:30:10December 1, 2020 | vs Kansas | 62 - 65 | Bankers Life Fieldhouse |
| 2020-12-06 17:00:22December 6, 2020 | at Georgia Tech | 62 - 79 | Atlanta State Farm Arena |
| 2020-12-12 12:00:08December 12, 2020 | Notre Dame | 64 - 63 | Rupp Arena |
| 2020-12-15 17:00:52December 15, 2020 | Detroit Mercy | 17:00:52Postponed | Rupp Arena |
| 2020-12-19 14:00:25December 19, 2020 | vs North Carolina | 63 - 75 | Cleveland Rocket Mortgage Fieldhouse |
| 2020-12-26 13:00:18December 26, 2020 | at Louisville | 59 - 62 | KFC Yum! Center |
| 2020-12-29 19:00:20December 29, 2020 | South Carolina | 19:00:20Postponed | Rupp Arena |
| 2021-01-02 18:00:36January 2, 2021 | at Mississippi State | 78 - 73 | Humphrey Coliseum |
| 2021-01-05 19:00:15January 5, 2021 | Vanderbilt | 74 - 77 | Rupp Arena |
| 2021-01-09 17:00:32January 9, 2021 | at Florida | 76 - 58 | Exactech Arena at Stephen C. O'Connell Center (Gainesville, FL) |
| 2021-01-12 21:00:02January 12, 2021 | Alabama | 85 - 65 | Rupp Arena |
| 2021-01-16 14:00:52January 16, 2021 | at Auburn | 59 - 66 | Auburn Arena |
| 2021-01-20 19:00:50January 20, 2021 | at Georgia | 19:00:507:00 pm | Stegeman Coliseum (Athens, GA) |
| 2021-01-23 18:00:01January 23, 2021 | LSU | 18:00:016:00 pm | Rupp Arena |
| 2021-01-26 19:00:13January 26, 2021 | at Alabama | 19:00:137:00 pm | Coleman Coliseum (Tuscaloosa, AL) |
| 2021-01-30 20:00:45January 30, 2021 | Texas | 20:00:458:00 pm | Rupp Arena |
| 2021-02-02 21:00:51February 2, 2021 | at Missouri | 21:00:519:00 pm | Mizzou Arena |
| 2021-02-06 20:00:17February 6, 2021 | Tennessee | 20:00:178:00 pm | Rupp Arena |
| 2021-02-09 19:00:44February 9, 2021 | Arkansas | 19:00:447:00 pm | Rupp Arena |
| 2021-02-13 13:00:10February 13, 2021 | Auburn | 13:00:101:00 pm | Rupp Arena |
| 2021-02-17 19:00:24February 17, 2021 | at Vanderbilt | 19:00:247:00 pm | Memorial Coliseum (Nashville, TN) |
| 2021-02-20 13:00:06February 20, 2021 | at Tennessee | 13:00:061:00 pm | Thompson-Boling Arena (Knoxville, TN) |
| 2021-02-23 19:00:18February 23, 2021 | Texas A&M | 19:00:187:00 pm | Rupp Arena |
| 2021-02-27 16:00:47February 27, 2021 | at Florida | 16:00:474:00 pm | Exactech Arena at Stephen C. O'Connell Center (Gainesville, FL) |
| 2021-03-02 21:00:59March 2, 2021 | at Mississippi | 21:00:599:00 pm | The Pavilion at Ole Miss |
| 2021-03-10 00:00:29March 10, 2021 | SEC Tournament First Round | 00:00:29TBD | Bridgestone Arena (Nashville, TN) |
| 2021-03-11 00:00:49March 11, 2021 | SEC Tournament Second Round | 00:00:49TBD | Bridgestone Arena (Nashville, TN) |
| 2021-03-12 00:00:42March 12, 2021 | SEC Tournament Quarterfinals | 00:00:42TBD | Bridgestone Arena (Nashville, TN) |
| 2021-03-13 00:00:32March 13, 2021 | SEC Tournament Semifinals | 00:00:32TBD | Bridgestone Arena (Nashville, TN) |
| 2021-03-14 00:00:27March 14, 2021 | SEC Tournament Championship | 00:00:27TBD | Bridgestone Arena (Nashville, TN) |