| 2020-11-12 19:00:19November 12, 2020 | | 19:00:197:00 pm | | Memorial Coliseum |
| 2020-11-20 21:00:21November 20, 2020 | | 21:00:219:00 pm | | Memorial Coliseum |
| 2020-11-25 18:00:15November 25, 2020 | Morehead | 45 - 81 | Kentucky | |
| 2020-11-29 13:00:05November 29, 2020 | University of Richmond | 76 - 64 | Kentucky | |
| 2020-12-01 21:30:10December 1, 2020 | Kentucky | 62 - 65 | Kansas | Bankers Life Fieldhouse |
| 2020-12-06 17:00:22December 6, 2020 | Kentucky | 62 - 79 | Georgia Tech | Atlanta State Farm Arena |
| 2020-12-12 12:00:08December 12, 2020 | Notre Dame | 64 - 63 | Kentucky | |
| 2020-12-15 17:00:52December 15, 2020 | Titans | 17:00:52Postponed | Kentucky | |
| 2020-12-19 14:00:25December 19, 2020 | Kentucky | 63 - 75 | North Carolina | Cleveland Rocket Mortgage Fieldhouse |
| 2020-12-26 13:00:18December 26, 2020 | Kentucky | 59 - 62 | Louisville | KFC Yum! Center |
| 2020-12-29 19:00:20December 29, 2020 | South Carolina | 19:00:20Postponed | Kentucky | |
| 2021-01-02 18:00:36January 2, 2021 | Kentucky | 78 - 73 | Mississippi State | Humphrey Coliseum |
| 2021-01-05 19:00:15January 5, 2021 | Vanderbilt | 74 - 77 | Kentucky | Rupp Arena |
| 2021-01-09 17:00:32January 9, 2021 | Kentucky | 76 - 58 | Florida | O'Connell Center |
| 2021-01-12 21:00:02January 12, 2021 | Alabama | 85 - 65 | Kentucky | Rupp Arena |
| 2021-01-16 14:00:52January 16, 2021 | Kentucky | 59 - 66 | Auburn | |
| 2021-01-20 19:00:50January 20, 2021 | Kentucky | 62 - 63 | Georgia | Stegeman Coliseum |
| 2021-01-23 18:00:01January 23, 2021 | Louisiana State | 69 - 82 | Kentucky | Rupp Arena |
| 2021-01-26 19:00:13January 26, 2021 | Kentucky | 59 - 70 | Alabama | Coleman Coliseum |
| 2021-01-30 20:00:45January 30, 2021 | Texas | 20:00:45Canceled | Kentucky | Rupp Arena |
| 2021-02-03 19:00:00February 3, 2021 | Missouri | 75 - 70 | Kentucky | Mizzou Arena |
| 2021-02-06 20:00:00February 6, 2021 | Kentucky | 71 - 82 | Tennessee | Rupp Arena |
| 2021-02-09 19:00:00February 9, 2021 | Kentucky | 80 - 81 | Arkansas | Rupp Arena |
| 2021-02-13 13:00:00February 13, 2021 | Kentucky | 82 - 80 | Auburn | Rupp Arena |
| 2021-02-17 19:00:00February 17, 2021 | Vanderbilt | 78 - 82 | Kentucky | Memorial Gymnasium |
| 2021-02-20 13:00:00February 20, 2021 | Tennessee | 55 - 70 | Kentucky | Thompson-Boling Arena |
| 2021-02-23 19:00:18February 23, 2021 | Kentucky | 19:00:18Canceled | Texas A & M | Rupp Arena |
| 2021-02-27 16:00:00February 27, 2021 | Florida | 71 - 67 | Kentucky | O'Connell Center |
| 2021-03-02 21:00:00March 2, 2021 | Mississippi | 70 - 62 | Kentucky | The Pavilion at Ole Miss |
| 2021-03-06 12:00:00March 6, 2021 | Kentucky | 92 - 64 | South Carolina | Rupp Arena |
| 2021-03-11 12:00:00March 11, 2021 | Kentucky | 73 - 74 | Mississippi State | Bridgestone Arena |