Final Record: Won: 4; Lost: 8
Head Coach: Edwin R. Sweetland
Assistant Coach(es): Robert Hoover Spahr
Manager: Leonard C. Bridges
Team Captain(s): William Rodes
Notes: Robert Spahr assumed coaching duties while E.R. Sweetland was ill
| Date | Game | Result | Score | Notes |
|---|---|---|---|---|
| 1/8/1910 | Kentucky at Kentucky Wesleyan | W | 14 – 12 OT | – |
| 1/22/1910 | Georgetown College at Kentucky | W | 31 – 11 | – |
| 1/24/1910 | DePauw at Kentucky | L | 11 – 24 | – |
| 1/28/1910 | Kentucky at Central University | L | 17 – 87 | – |
| 2/4/1910 | Kentucky at Georgetown College | L | 16 – 34 | – |
| 2/7/1910 | Kentucky at Cincinnati | L | 17 – 47 | – |
| 2/9/1910 | Kentucky at DePauw | L | 16 – 28 | – |
| 2/10/1910 | Kentucky at Rose Polytechnic | L | 11 – 52 | – |
| 2/16/1910 | Tennessee at Kentucky | W | 26 – 5 | – |
| 3/5/1910 | Central University at Kentucky | L | 13 – 31 | State Championship Game |
| 3/8/1910 | Georgetown College at Kentucky | W | 24 – 23 | – |
| 3/11/1910 | Kentucky at Central University | L | 9 – 51 | – |